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      1 2 › 2

      2 Endoscopy
      5 EUS
      D Duodenum
      E Gallbladder and Biliary tree
      G Pancreas
      U Surgical
      6 Radiology
      neuroendocrine, signet ring cell, papillary carcinoma, lucidi cristina, minen, non-neuroendocrine, pernazza, pernazza graziano

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      Author: LUCIDI Cristina Roma Italy

      62y female patient with jaundice and increased transaminases/cholestasis, responsive to UDCA. Abdominal CT and MRI showed dilated VBP with papilla rat-tail narrowing and suspected material inside. Normal Ca 19-9 level.  Histopathological examination confirmed a Signet ring cell carcinoma of the papilla.

      The surgical specimen revealed a mixed neuroendocrine/non-neuroendocrine neoplasm (MiNEN) with large cell neuroendocrine carcinoma (LCNEC) mixed with intestinal signet ring cell adenocarcinoma HGD. pT3aN0(i+) R0 HG (courtesy of Dr Graziano PERNAZZA)

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